The Laser of the ALICE Time Projection Chamber

The large TPC ($95 \mathrm{m}^3$) of the ALICE detector at the CERN LHC was commissioned in summer 2006. The first tracks were observed both from the cosmic ray muons and from the laser rays injected into the TPC. In this article the basic principles of operating the $266 \mathrm{nm}$ lasers are presented, showing the installation and adjustment of the optical system and describing the control system. To generate the laser tracks, a wide laser beam is split into several hundred narrow beams by fixed micro-mirrors at stable and known positions throughout the TPC. In the drift volume, these narrow beams generate straight tracks at many angles. Here we describe the generation of the first tracks and compare them with simulations.Comment: QM06 poster proceedings, 6 pages, 4 figure

PRM51 From Clinical Trial to Real-World Evidence: A Systematic Approach to Identifying Data Sources for Observational Research

Edifici industrial de dos cossos de planta baixa i tres plantes pis acabades amb mansarda. Destaca el nombre i dimensions de les obertures que permeten una gran entrada de llum a l'interior i l'amplitud de les plantes diàfanes.Digitalitzat per Tecnodo

Ultrastable lasers based on vibration insensitive cavities

We present two ultra-stable lasers based on two vibration insensitive cavity designs, one with vertical optical axis geometry, the other horizontal. Ultra-stable cavities are constructed with fused silica mirror substrates, shown to decrease the thermal noise limit, in order to improve the frequency stability over previous designs. Vibration sensitivity components measured are equal to or better than 1.5e-11 per m.s^-2 for each spatial direction, which shows significant improvement over previous studies. We have tested the very low dependence on the position of the cavity support points, in order to establish that our designs eliminate the need for fine tuning to achieve extremely low vibration sensitivity. Relative frequency measurements show that at least one of the stabilized lasers has a stability better than 5.6e-16 at 1 second, which is the best result obtained for this length of cavity.Comment: 8 pages 12 figure

INTEGRAL observations of the Large Magellanic Cloud region

We present the preliminary results of the INTEGRAL survey of the Large Magellanic Cloud. The observations have been carried out in January 2003 (about 10^6 s) and January 2004 (about 4x10^5 s). Here we concentrate on the bright sources LMC X-1, LMC X-2, LMC X-3 located in our satellite galaxy, and on the serendipitous detections of the Galactic Low Mass X-ray Binary EXO 0748-676 and of the Seyfert 2 galaxy IRAS 04575-7537.Comment: 4 pages, 7 figures. To be published in the Proceedings of the 5th INTEGRAL Workshop: "The INTEGRAL Universe", February 16-20, 2004, Munic

Predictive Monitoring of Business Processes

Modern information systems that support complex business processes generally maintain significant amounts of process execution data, particularly records of events corresponding to the execution of activities (event logs). In this paper, we present an approach to analyze such event logs in order to predictively monitor business goals during business process execution. At any point during an execution of a process, the user can define business goals in the form of linear temporal logic rules. When an activity is being executed, the framework identifies input data values that are more (or less) likely to lead to the achievement of each business goal. Unlike reactive compliance monitoring approaches that detect violations only after they have occurred, our predictive monitoring approach provides early advice so that users can steer ongoing process executions towards the achievement of business goals. In other words, violations are predicted (and potentially prevented) rather than merely detected. The approach has been implemented in the ProM process mining toolset and validated on a real-life log pertaining to the treatment of cancer patients in a large hospital

JEM-X background models

Background and determination of its components for the JEM-X X-ray telescope on INTEGRAL are discussed. A part of the first background observations by JEM-X are analysed and results are compared to predictions. The observations are based on extensive imaging of background near the Crab Nebula on revolution 41 of INTEGRAL. Total observing time used for the analysis was 216502 s, with the average of 25 cps of background for each of the two JEM-X telescopes. JEM-X1 showed slightly higher average background intensity than JEM-X2. The detectors were stable during the long exposures, and weak orbital phase dependence in the background outside radiation belts was observed. The analysis yielded an average of 5 cps for the diffuse background, and 20 cps for the instrument background. The instrument background was found highly dependent on position, both for spectral shape and intensity. Diffuse background was enhanced in the central area of a detector, and it decreased radially towards the edge, with a clear vignetting effect for both JEM-X units. The instrument background was weakest in the central area of a detector and showed a steep increase at the very edges of both JEM-X detectors, with significant difference in spatial signatures between JEM-X units. According to our modelling, instrument background dominates over diffuse background in all positions and for all energies of JEM-X.Comment: 4 pages, 3 figures, A&A accepted (INTEGRAL special issue

EUPATI: Collaboration between patients, academia and industry to champion the informed patient in the research and development of medicines

The value of collaborations and partnerships between different stakeholders to achieve optimum outcomes in the medicines research and development process is being recognised. Historically, there has been a lack of collaboration with patients and many research consortiums consisting mainly of academia and/or industry partners. Although patient experts are able to bring valuable first-hand experience and insights, they might not possess detailed knowledge about medicines research and development to actively participate in the collaboration process. The European Patients’ Academy on Therapeutic Innovation (EUPATI) was established to deliver training to patient experts, and education resourcesto patient advocates and members of the health-interested public across Europe. EUPATI was launched in February 2012 and is a patient-led Innovative Medicines Initiative (IMI) project, with a multi-stakeholder consortium of patient advocates, academia, industry and not-for-profit organisations. Training and educational materials will be used for capacity building among patients, for educating patient advocates and for informing the health-interested public. The successful uptake of EUPATI’s materials will hopefully translate into a new paradigm of increased patient involvement across the entire medicines research and development process, bringing mutual benefits, including better medicines, to all stakeholders